Painless Needle Free Vaccination Zycov D[DNA Vaccine]

Say goodbye to Needles, ZyCov-D is painless distribution and minimizes irritation and side effects that occur on the area of vaccination. It is well-liked by people suffering from diabetes and used in the administering insulin. ZyCov-D for COVID-19 is the first needle-free plasmid DNA vaccination. ZyCov-D can be administered to Dermis (inner layers of skin) which is located between the epidermis as well as the hypodermis by using an applicator that is needle-free

Who Is Making It?

The Ahmedabad-based pharmaceutical company, Cadila Healthcare Ltd (Zydus Cadila) began making a plasmid-DNA vaccine against Covid-19 as early in the month of February 2020. Use for adolescents (above 12 years old) as well as the adult population of India.

How ZyCov-D Executed ?

In contrast to the Covid-19 vaccines which are administered to muscle tissue with a needle ZyCov-D can be administered using the Pharma Jet needle-free applicator to ensure effortless treatment. ZyCov-D is a three dose vaccine that is administered over a period between 28 and 56 days. The dosage of the entire vaccine is 6 milligrams (6mg) delivered in three doses each of 2 mg. Each dose will be administered to “two sites”, e.g. both arms. So, to get each dose, the person must receive two doses of 1 mg each in two different places.

How Does ZyCov-D Work?

ZyCov-D is an DNA vaccine. That means it utilizes a tiny piece of DNA from the virus to initiate an immune reaction. The DNA material is introduced through the body with an applicator that is needle-free, and releases tiny drops of vaccine through the skin.

When the genetic material has been deposited in your body, it tells cells to create a harmless part of virus, referred to as the spike protein. These antibodies are then able to recognize and fight the real virus, if someone will be exposed to the virus later on.

Clinical Clinical Trials

ZyCov-D is being studied in phases 1, 2, and 3 clinical trials, which involved over 28,000 individuals. The majority of the people were between 12-18 years old.

Clinical Trials In The Preclinical Stage

In February of 2020, Cadila Health was able to create an DNA-plasmid that was based on COVID-19-based vaccine in its Vaccine Technology Centre (VTC) located in Ahmedabad. The candidate for the vaccine had the ability to complete preliminary clinical trials conducted on animal models without issue. The study’s report was released via bio which was then published in Vaccine. Then, the clinical trials on humans for Phases I and II were deemed acceptable by the regulator. The regulator also approved the Phase I and II trials.

Phase 1 And 2 Trials

Phase I tests of the vaccine’s candidate for use began on July 15th, 2020, which continued to run until the end of October 2020. The candidate for the vaccine was evaluated with healthy people between the ages of 18 and 55 and lasted 28 days between the three doses.


Cadila Healthcare started Phase II studies of its vaccine candidate on 6 August 2021 and involved more than 1,000 participants as part of the multi-centric adaptive phase I/II dose escalation, random double-blind placebo-controlled method. The company announced the phase II trials had been finished by the end of November 2020.

Phase 3 Trial

In November of 2020 the company made an announcement that they will test its vaccine candidate with a population of 30,000 people who are in phase III trials. In the month of January 2021 The Drugs Controller General of India (DCGI) gave permission to conduct the phase III clinical trials on 28216 Indian patients within the 1299-year age group. From this group approximately 1,000 people comprised the 12–18 age group. Initial results of the Phase III trials were published in July 2021.

The 1st July of 2021 was the date Cadila Healthcare announced the effectiveness of its product to be 66.6 percent for COVID-19 that is symptomatic and 100 percent against severe or moderate disease, in the initial analysis of its Phase 3 trial results.

10 Benefits Of The Zycov-D

Vaccination Refusal, syringe ban vector sign.

  • The first DNA vaccine to treat COVID-19 ZyCov-D is the very first DNA vaccine accepted for use in emergency situations against COVID-19. It could open the way to the creation of additional DNA-based vaccinations to come in the future.
  • Three-dose regimen: ZyCov D is delivered in three doses and may be more effective in protecting against COVID-19 as compared to other vaccines, which only require two doses.
  • Cost-effective: Manufacturing processes for DNA ZyCov-D vaccines is quite affordable that could be more affordable for those with a small amount of resources.
  • Storage and transportation is simple DNA vaccines can be kept and shipped with normal temperatures for refrigeration This makes it easier to use in locations with little refrigeration infrastructure.
  • A good safety profile ZyCov-D was discovered to be secure and safe during clinical trials. There were none of the serious adverse reactions reported.
  • The potential to prove successful against variants of the virus: Zydus Cadila is working on the variant-specific version ZyCov-D which could prove efficient against new variants of ZyCov-D.
  • The ZyCov-D age range is broad. It was tested on participants who were between the ages of 12 and over This makes it the best choice for large range of ages.
  • Single-use vials: Zycov-D is available in single-use vials which can lower the risk of infection and also help to ensure the effectiveness and quality of the vaccination.
  • The immune system is strong: In clinical tests, Zycov-D has been shown to trigger a powerful immune response in the face of SARS-CoV-2 virus.
  • Possibly effective in preventing asymptomatic infections Although Zycov-D is being tested for its effectiveness in tackling COVID-19 symptoms that are symptomatic however, it could help in reducing the chance of developing asymptomatic infections and transmission.

5 Side Effects of Zycov-D

  • The tenderness or pain that occurs around the injection site : This is a common adverse reaction reported following the injection of Zycov-D Some patients feeling tenderness, pain or swelling near the place of the injection.
  • Fatigue: Some patients who participated in clinical trials complained of feeling exhausted or tired after taking Zycov-D however the effect was usually minor and resolved in its own.
  • Headache: Headaches have been reported by some patients following the vaccination, however, they tend to be mild and resolve by themselves.
  • Fever is an extremely frequent side effect associated with ZycovD. However, some patients may be seeing a slight rise in body temperature during the couple of days after the the vaccination.
  • Muscle pain: A few participants during clinical trials complained of muscular pains and body aches. However, the side effects of Zycov-D were usually moderate and resolved by themselves within several days.

When Will Zycov D Be Released?

Zycov-D is already granted Emergency Use Authorization (EUA) by the Drug Controller General of India (DCGI) and is being introduced in India. The vaccine received EUA on the basis of results of clinical trials in phase 3 and concluded that Zycov D is safe and effective at the prevention of COVID-19 symptoms.

Zydus Cadila, the manufacturer of Zydus Cadila, has also made plans to apply for approval from the regulatory authorities for Zycov-D in different nations, such as Brazil, Mexico, and the Philippines. The timeframe to obtain regulatory approval and the availability of Zycov-D in these countries could differ.

It’s important to remember that worldwide availability of COVID-19 vaccines are very limited and demands for the vaccine continues to surpass availability. That means, even following the approval of regulatory authorities, there could be delays in distribution of Zycov-D in certain countries. One of the best ways to remain up-to-date on the availability of Zycov D for your location is to inquire with your local health officials or your healthcare professional.

Zydus’ Zycov D Vaccine: A Needle-Free Solution To The Corona Crisis


Zydus Cadila’s Zycov-D vaccination has been described as a game changer in the fight against COVID-19 epidemic, due to the innovative needle-free delivery method providing a more efficient and affordable option to get vaccinated.

Contrary to conventional vaccines, which generally are delivered by injection using needles, Zycov-D uses a novel technique known as”the “needle-free system,” or NDDS which is used for administering the vaccine. It is a tiny device that utilizes a high pressure stream of liquid to inject the vaccine directly into the skin with no need for needles.

This can also lower the possibility of injury from needle-sticks and reduce the requirement to dispose of needles, which is a logistical problem in some environments.

Zycov-D is already awaiting the emergency use approval (EUA) through the Drug Controller General of India (DCGI) and is being introduced in India. It has been proven to be safe and efficient through clinical trials as well as the needle-free delivery method is well-accepted by patients.


Zycov-D’s needle-free delivery method is an appealing solution to the COVID-19 epidemic, and may assist in increasing the accessibility of vaccines across a greater variety of environments. In the event that the global effort to get vaccines is ongoing, it’s essential to explore new and easy delivery strategies in order to make vaccines accessible to all who require they.


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